Amphiphilic poly{[α-maleic anhydride-ω-methoxypoly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery
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چکیده
منابع مشابه
Amphiphilic poly{[α-maleic anhydride-ω-methoxy-poly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery
In this study, the transdermal drug delivery properties of D,L-tetrahydropalmatine (THP)-loaded amphiphilic poly{[alpha-maleic anhydride-omega-methoxy-poly(ethylene glycol)]-co-(ethyl cyanoacrylate)} (PEGECA) graft copolymer nanoparticles (PEGECAT NPs) were evaluated by skin penetration experiments in vitro. The transdermal permeation experiments in vitro were carried out in Franz diffusion cel...
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BACKGROUND AND METHODS A new amphiphilic comb-shaped copolymer (SP) was synthesized by conjugating poly(styrene-co-maleic anhydride) with low molecular weight polyethyleneimine for gene delivery. Fourier transform infrared spectrum, (1)H nuclear magnetic resonance, and gel permeation chromatography were used to characterize the graft copolymer. RESULTS The buffering capability of SP was simil...
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Delivery of drug through Transdermal route represents a most convenient and novel approach. Transfersomes were found to be more effective as they render controlled release of drug due to depot formation in skin and were more effective in transdermal delivery. Transfersomes are applied to the skin and permeate through the stratum corneum lipid lamellar regions as a result of the hydration and os...
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ژورنال
عنوان ژورنال: International Journal of Nanomedicine
سال: 2009
ISSN: 1178-2013
DOI: 10.2147/ijn.s7814